Leqvio
What does Leqvio Treat?
- Heterozygous familial hypercholesterolemia (HeFH)
- Clinical atherosclerotic cardiovascular disease (ASCVD), who require additional lowering of LDL-C
Treatment Cycle and Duration
Cycle: The first two injections 3 months apart then every 6 months thereafter
Duration:
Side Effects
Injection site reaction
Joint pain
Urinary tract infection
Diarrhea
Bronchitis
Pain in extremities
Dyspnea
How Does Leqvio Work?
TREATMENT EDUCATION
Leqvio is a small interfering RNA for LDL-C reduction that selectively targets the liver. After Leqvio administration, it is selectively taken up by the liver cells. Leqvio is rapidly cleared from the bloodstream and reaches undetectable levels within 48 hours after administration. Leqvio is slowly released inside the cell where it loads onto the RNA induced silencing complex (RISC). Once loaded the complex that consists of Leqvio and the body’s naturally occurring RISC successively cuts multiple copies of PCSK9 mRNA continuously, preventing its production to increase the number of LDL receptors on the surface of the liver cells, which results in greater liver acceptance of circulating LDL-C, as a result Leqvio reduces LDL-C in the bloodstream.
What to Expect During Your Infusion
- Pure doesn’t believe in waiting rooms. You’ll be taken to your own private suite where you’ll check in and your nurse will take your vitals and complete a pre-infusion assessment.
- To begin the infusion, an IV line will be inserted into your arm or hand. The medication will be connected and the nurse will monitor the infusion carefully, especially the first few minutes, to watch for reactions or side effects and make sure you’re comfortable.
- When the infusion is complete, your IV will be removed and the nurse will apply a bandage. Your nurse will give you instructions on side effects to watch for and when to seek help. You may be asked to stay for a short observation period.
- You can resume normal activities, though you may feel tired or need to rest. Drink water and eat a light meal to help with fatigue or nausea.
