Briumvi
What does Briumvi Treat?
- Multiple sclerosis (Clinically isolated syndrome)
- Relapsing-remitting disease
- Active secondary progressive disease
Treatment Cycle and Duration
Cycle: 1st and 2nd infusion 15 days apart. Then every 24 weeks.
Duration: 1 to 4 hours
Side Effects
Infusion reactions
Upper respiratory tract infections
Bacterial and viral infections
Fever
Nausea
Flu-type symptoms
Throat irritation
Flushing
Hepatitis B reactivation
Progressive Multifocal Leukoencephalopathy (PML) is possible but has not been observed
How Does Briumvi Work?
TREATMENT EDUCATION
In people with MS, their own immune system (B-lymphocytes) attack the myelin sheath, which is the protective covering on nerve cells in the central nervous system. When these B-cells are being produced, they have a CD20 marker which helps to identify them. As the myelin sheath erodes, nerve cells become damaged, preventing them from communicating and sending signals to each other. Over time, this can affect motor skills, speech, bowel function, balance, and vision. Briumvi infusion is not a cure for MS, however, it is able to target the CD20 marker on B lymphocytes to destroy them so they can no longer harm the nerve cells. This is a way of suppressing the body’s overactive immune response.
What to Expect During Your Infusion
- Pure doesn’t believe in waiting rooms. You’ll be taken to your own private suite where you’ll check in and your nurse will take your vitals and complete a pre-infusion assessment.
- To begin the infusion, an IV line will be inserted into your arm or hand. The medication will be connected and the nurse will monitor the infusion carefully, especially the first few minutes, to watch for reactions or side effects and make sure you’re comfortable.
- When the infusion is complete, your IV will be removed and the nurse will apply a bandage. Your nurse will give you instructions on side effects to watch for and when to seek help. You may be asked to stay for a short observation period.
- You can resume normal activities, though you may feel tired or need to rest. Drink water and eat a light meal to help with fatigue or nausea.
